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Scotland, B.L., Dharmaraj, S., Cottingham, A.L., Truong, N., Chapoval, S.P., Keegan, A.D., Pearson, Ryan M.* Impact of antigen loading in tolerogenic nanoparticles to mitigate Th2-mediated allergic lung inflammation. Drug Delivery and Translational Research 2024. In Press.  

Scotland, B.L., Shaw, J.R., Dharmaraj, S., Caprio, N., Cottingham, A.L., Lasola, J.J.M., Sung, J., Pearson, Ryan M.* Cell and biomaterial delivery strategies to induce immune tolerance. Advanced Drug Delivery Reviews 2023. In Press.  

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Truong, N., Cottingham, A.L., Dharmaraj, S., Shaw, J.R., Lasola, J.J.M., Goodis, C.C., Fletcher, S., Pearson, Ryan M.* Multimodal nanoparticle-containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation. Bioengineering & Translational Medicine 2023. In Press.  

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Scotland, B.L., Cottingham, A.L., Lasola, J.J.M., Hoag, S.W., Pearson, Ryan M.* Protein-polymer conjugate nanoparticles to elucidate dendritic and antigen-specific CD4+ T cell responses for immunotherapy development. ACS Applied Polymer Materials 2023. In Press.  


Zhang M.H., Scotland B.L., Jiao, Y., Slaby, E.M., Truong, N., Stephanie, G., Szeto, G.L.,* Pearson, Ryan M.* Lipid-polymer hybrid nanoparticles utilize B cells and dendritic cells to elicit distinct antigen-specific CD4+ and CD8+ T cell responses. ACS Applied Bio Materials 2023. In Press. *Co-corresponding authors.


Pearson, Ryan M.*, Acharya, A.P., Moon, J.J. Emerging immunotherapeutics for immune activation and tolerance (Preface). Drug Delivery and Translational Research 2023. DOI: 10.1007/s13346-023-01352-5.



Chakraborty, A., Dharmaraj, S., Truong, N., and Pearson, Ryan M.* Excipient-free ionizable polyesters for lung-selective and innate immune cell plasmid DNA and mRNA transfection. ACS Applied Materials & Interfaces 2022. 14, 51, 56440-56453.  

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Casey, L.M., Decker, J.T., Podojil, J.R., Rad, L., Hughes, K.R., Rose, J.A., Pearson, Ryan M., Miller, S.D., and Shea, L.D. Nanoparticle dose and antigen loading attenuate antigen-specific T cell responses. Biotechnology & Bioengineering 2022. 120 (1), 284, 296.


Truong, N., Goodis, C., Cottingham, A.L., Shaw, J., Fletcher, S., Pearson, Ryan M.* Modified suberoylanilide hydroxamic acid reduced drug-associated immune cell death and organ damage under lipopolysaccharide inflammatory challenge. ACS Pharmacology & Translational Science 2022. 5, 11, 1128-1141.


Shaw, J., Pearson, Ryan M.* Nanoparticle Personalized Biomolecular Corona: Implications of Pre-existing Conditions on Immunomodulation and Cancer. Biomaterials Science 2022. 10, 2540-2549.


Yu, W., Popescu, C., Ibrahim, A., Pearson, Ryan M., MacKerell, A.D., Yu, D., Wang, F., and Hoag, S.W., Cholecalciferol complexation with hydroxypropyl-b-cyclodextrin (HPBCD) and its molecular dynamics simulation. Pharmaceutical Development and Technology 2022. DOI: 10.1080/10837450.2022.2064492.

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Casey, L.M., Hughes, K.R., Saunders, M.N., Miller, S.D., Pearson, Ryan M.,* and Shea, L.D.,* Mechanistic contributions of Kupffer cells and liver sinusoidal endothelial cells in nanoparticle-induced antigen-specific immune tolerance. Biomaterials 2022. 283, 121457 * Co-corresponding authors.

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Zhang M.H., Scotland B., Jiao, Y., Slaby, E.M., Truong, N., Stephanie, G., Pearson Ryan M.*, and Szeto G.L.,* Lipid-polymer hybrid nanoparticles utilize B cells and dendritic cells to elicit distinct antigen-specific CD4+ and CD8+ T cell responses. BioRxiv 2022. DOI: 10.1101/2022.01.23.477398. (preprint).

*Co-corresponding authors.

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Truong, N., Black, S.K., Shaw, J., Scotland, B.L, Pearson, Ryan M.,* Microfluidics-generated immunomodulatory nanoparticles and formulation-dependent effects on lipopolysaccharide-induced macrophage inflammation. The AAPS Journal 2022. 24:6.


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Lasola, J.J.M., Cottingham, A.L., Scotland, B.L., Truong, N., Hong, C.C., Shapiro, P., Pearson, Ryan M.,* Immunomodulatory Nanoparticles Mitigate Macrophage Inflammation via Inhibition of PAMP Interactions and Lactate-Mediated Functional Reprogramming of NF-κB and p38 MAPK. Pharmaceutics 2021. 13, 1841.

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Chakraborty, A., Ciciriello, A.J., Dumont, C.M.*, and Pearson, Ryan M.,* Nanoparticle-based delivery to treat spinal cord injury. AAPS PharmSciTech 2021. 22 (3), 1-9. *Co-corresponding authors.


Chakraborty, A., Gvozdenovic-Jeremic, J., Wang, F., Hoag, S.W., Vert-Wong, K., and Pearson, Ryan M.,* Hedgehog pathway inhibitors significantly reduce the formation of heterotopic ossification in a direct trauma/burn mouse model. BioRxiv 2021. DOI: 10.1101/2021.01.31.429058. (preprint).



Chakraborty, A., Lasola, J.J.M., Truong, N., Pearson, Ryan M.,* Serum-independent non-viral gene delivery to innate and adaptive immune cells using immunoplexes. ACS Applied Bio Materials 2020. 3, 9, 6263-6272

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Lasola, J.J.M., Kamdem, H., McDaniel, M., Pearson, Ryan M.,* Biomaterial-driven immunomodulation: Cell biology-based strategies to mitigate severe inflammation and sepsis. Frontiers in Immunology 2020. DOI: 10.3389/fimmu.2020.01726.


Freitag, T., Podojil, J.R., Pearson, Ryan M., Fokta, F., Sahl, C., Messing, M., Andersson, L., Leskinen, K., Saavalainen, P., Hoover, L., Huang, K., Phippard, D., Makeki, S., King, J.C., Shea, L.D., Miller, S.D., Getts, D.R. Gliadin nanoparticles induce immune tolerance to gliadin in mouse models of celiac disease. Gastroenterology 2020. 158(6), pp 1667-1681.


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Casey, L.M., Kakade, S., Decker, J.T., Rose, J., Deans, K., Shea, L.D.*, Pearson, Ryan M.* Cargo-less nanoparticles program innate immune cell responses to Toll-like receptor activation.  Biomaterials 2019. 218, 119333. * Co-corresponding authors.


Saito, E., Kuo, R., Pearson, Ryan M., Gohel, N., Cheung, B., King, N.J., Miller, S.D., Shea, L.D. Designing drug-free biodegradable nanoparticles to modulate inflammatory monocytes and neutrophils for ameliorating inflammation.  Journal of Controlled Release 300, (2019), 185-196.

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Skoumal, M., Woodward, K.B., Zhao, H., Wang, F., Yolcu, E.S, Pearson, R.M., Hughes, K.R., Garcia, A.J., Shea, L.D., Shirwin, H. Localized immune tolerance from FasL-functionalized PLG scaffolds. Biomaterials 192, (2019), 271-281. 


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Pearson, Ryan M.,* Podojil, J.R.,* King, N.J., Shea, L.D., Miller, S.D., Getts, D.R. Overcoming challenges in treating autoimmunity: Development of tolerogenic immune-modifying nanoparticles. Nanomedicine: NBM 2019, 18, pp 282-291 *co-first author

Casey, L.M.,* Pearson, Ryan M.,* Hughes, K.R., Liu, J.M.H., Rose, J.A., North, M.G., Wang, L.Z., Lei, M., and Shea, L.D. Conjugation of TGF-β to antigen-loaded PLGA nanoparticles enhances efficiency of antigen-specific tolerance. Bioconjugate Chemistry 2018, 29 (3), pp 813–823. *co-first author


Pearson, Ryan M., Casey, L.M., Hughes, K.R., Miller, S.D., and Shea, L.D. In Vivo Reprogramming of Immune Cells: Technologies for Induction of Antigen-specific Tolerance. Advanced Drug Delivery Reviews 2017. 114, pp 240-255.

Pearson, Ryan M., Casey, L.M., Hughes, K.R., Wang, L.Z., North, M.G., Getts, D.R., Miller, S.D., and Shea, L.D. Controlled Delivery of Single or Multiple Antigens in Tolerogenic Nanoparticles using Peptide-polymer Bioconjugates. Molecular Therapy 2017. 25(7), pp 1655-1664.

McCarthy, D.P., Yap, W.T., Harp, C.T., Song, W.K., Chen, J., Pearson, Ryan M., Miller, S.D., and Shea, L.D. An Antigen-encapsulating Nanoparticle Platform for TH1/17 Immune Tolerance Therapy. Nanomedicine: NBM 2016. 13(1), pp 191-200.


Pearson, Ryan M., Sen, S., Hsu, H., Gaske, M., Pasko, M., Král, P. and Hong, S. Tuning the Selectivity of Dendron Micelles through Variations of the PEG Corona. ACS Nano 2016. 10(7), pp 6905-6914.

Smarr, C.B., Yap, W.T., Neef, T.P, Pearson, Ryan M., Hunter, Z.N., Ifergan, I., Getts, D.R., Bryce, P.J., Shea, L.D., and Miller, S.D. Biodegradable Antigen-Associated PLG Nanoparticles Tolerize Th2 Mediated Allergic Airway Inflammation Pre- and Post-Sensitization. Proceedings of the National Academy of Science of the United States of America 2016. 113(18), pp 5059-5064.

Bugno, J., Hsu, H-j., Pearson, Ryan M., Noh, H., and Hong, S. Size and Surface Charge of Engineered Poly(amidoamine) Dendrimers Modulate Tumor Accumulation and Penetration: A model study using multicellular tumor spheroids. Molecular Pharmaceutics 2016. 13(7), pp 2155-2163.

Pearson, Ryan M., Juettner, V.J., and Hong, S. Biomolecular Corona on Nanoparticles: A Survey of Recent Literature and its Implications in Targeted Drug Delivery. Frontiers in Chemistry 2014. 2(108). DOI: 10.3389/fchem.2014.00108


Hsu, H., Sen, S., Pearson, Ryan M., Král, P., and Hong, S. Poly(ethylene glycol) Corona Chain Length Controls End-Group-Dependent Cell Interactions of Dendron Micelles. Macromolecules, 2014. 47(19), pp 6911-6918.

Pearson, Ryan M., Hsu, H., Bugno, J., and Hong, S. Understanding Nano-bio Interactions to Improve Nanocarriers for Drug Delivery. MRS Bulletin 2014. 39(3), pp 227-237.

Yang, Y., Pearson, Ryan M., Lee, O., Chatterton, RT., Khan, SA., and Hong, S. Dendron-based micelles for Topical Delivery of Endoxifen: A Potential Chemo-Preventive Medicine for Breast Cancer. Advanced Functional Materials 2014. 24(17), pp 2442-2449.

Pearson, Ryan M., Patra, N., Hsu, H., Uddin, S., Král, P. and Hong, S. Positively Charged Dendron Micelles Display Negligible Cellular Interactions. ACS Macro Letters 2013, 2, pp 77-81. 



Pearson, Ryan M., Sunoqrot, S., Hsu, H., J.W. Bae, and Hong, S. Dendritic Nanoparticles: The next generation of nanocarriers? Therapeutic Delivery 2012, 3(8), pp 941-959.

Sunoqrot, S., Bae, JW., Pearson, Ryan M., Shyu, K., Liu, Y., and Hong, S. Temporal Control over Cellular Targeting through Hybridization of Folate-targeted Dendrimers and PEG-PLA Nanoparticles. Biomacromolecules 2012, 13 (4), pp 1223-1230.


Bae, JW.,* Pearson, Ryan M.,* Patra, N., Sunoqrot, S., Vukovic, L., Král, P. and Hong, S. Dendron-mediated Self-assembly of Highly PEGylated Block Copolymers: A Modular Nanocarrier Platform. Chemical Communications 2011, 47, pp 10302-10304. *co-first author

Sunoqrot, S., Jin, S-E., Bae, JW., Pearson, Ryan M., Liu, Y. and Hong, S. Kinetically Controlled Cellular Interactions of Polymer-Polymer and Polymer-Liposome Nanohybrid Systems. Bioconjugate Chemistry 2011, 22 (3), pp 466-474.

Myung, JH., Gajjar, K., Pearson, Ryan M., Launiere, C., Eddington, D. and Hong, S. Direct Measurements on CD24-Mediated Rolling of Human Breast Cancer MCF-7 Cells on E-selectin. Analytical Chemistry 2011, 83 (3), pp 1078–1083; highlighted: C&EN (January 13, 2011).

Titov, A. V., Král, P. and Pearson, Ryan M., Sandwiched Graphene-membrane Superstructures. ACS Nano 2010, (4) 229-234.


Book Chapters

Hsu, H-j., Pearson, Ryan M., and Hong, S. Multifunctional Dendritic Nanoparticles as a Nanomedicine Platform. In: Rege, E., editor. Cancer Therapeutics and Imaging: Molecular and cellular engineering and nanobiomedicine. World Scientific Publishing Co., Ptd. 2018.

Pearson, Ryan M., Myung, JH., and Hong, S. Engineering Multifunctional Devices through Implementation of Bio-inspired Design Strategies. In: Jabbari, E., Khademhosseini, A., Lee, L.P., Kim, D., and Ghaemmaghami, A. editors. Handbook of Biomimetics and Bioinspiration. World Scientific Publishing Co., Ptd. 2013. ISBN: 978-9814354929.

Pearson, Ryan M., Bae JW., and Hong, S. Multifunctional Dendritic Nanocarriers and Their Promising Application for Targeted Drug Delivery. In: Yeo, Y., editor. Nanoparticulate drug delivery systems: Strategies, Technologies, and Applications. Wiley-VCH. 2013. ISBN: 978-1-118-14887-7.

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